My research interest is focused on the understanding the role of polyamines in the cell using E. coli as a model system. Elucidation of the role of polyamines in global gene expression is my major research interest. Identification of genes regulated by polyamines and uncovering underlying mechanisms of the polyamine-dependent gene regulation is the areas of study at present time.
My research interest also extends to E. coli host development for production of biotech products by genetic engineering. Metabolic engineering of E. coli in particular modification of the inherited physiology of the host strain for enhanced product productivity is my major interest.
학력
(PhD) 1987 Dept. of Microbiology and Cell Science, University of Florida, Gainesville
약력/경력
1992 - Present Professor, Dept. of Biological Sciences, Sungkyunkwan University
1988 - 1992 Research Associate, Yale University
1987 - 1988 Research Associate, University of Florida
1999 ? 2011 CEO, Microgenix
1992-3/1995-7/1999-2001/2002-4/2004-5/ 2005-6 Chairman, Dept. of Biological Sciences, Sungkyunkwan University
학술지 논문
(2014)
Two mechanisms for putrescine-dependent transcriptional expression of the putrescine aminotransferase gene, ygjG, in Escherichia coli.
ARCHIVES OF MICROBIOLOGY.
196,
9
(2007)
Role of Polyamine in Transcriptional Regulation of ygjG Encoding Putrescine Aminotransferase in Escherichia coli: Dual Regulation of ygjG by Two Different Sigma Factors, RpoS and RpoN.
성균관대학교 박사학위 논문.
(2007)
Characterization of Catabolite Repression and Propionate Resistant Mutant of Escherichia coli.
성균관대학교 석사학위논문.
(2007)
Construction and Characterization of E. coli mutant altered in propionate metabolism.
성균관대학교 석사학위논문.
(2007)
Studies of Genetic Analysis to Elucidate the Role of Polyamine in Escherichia coli.
성균관대학교 석사학위 논문.
(2006)
Catalase-peroxidase of Mycobacterium bovis BCG converts isoniazid to isonicotinamide, but not to isonicotinic acid: Differentiation parameter between enzymes of Mycobacterium bovis BCG and Mycobacterium tuberculosis.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS.
1760,
(2005)
Cloning and expression of superoxide dismutase from Mycobacterium bovis BCG.
PROTEIN EXPRESSION AND PURIFICATION.
47,
(2005)
Cloning and expression of superoxide dismutase from Mycobacterium bovis BCG.
PROTEIN EXPRESSION AND PURIFICATION.
(2002)
Polyamine Stimuation of arcA Expression in Escherichia coli.
JOURNAL OF MICROBIOLOGY.
40,
4
(1999)
Optimal Protocol for Enumeration of Attached Bacteria on Glass Slides.
J of Microbiology.
37,
4
(1999)
Identification of the Polyamine Induced proteins in Escherichia coli.
MOLECULES AND CELLS.
9,
2
단행본
(1998)
미생물학 실험서.
(주) 을유문화사.
공동
특허/프로그램
유기산 생성이 억제된 대장균 변이주.
95-038044.
19980619.
대한민국
학술회의논문
(2007)
Suppression of Polyamine-Dependent Growth of a Polyamine Auxotroph (del-speB del0speC).
2007 International Meeting of the Federation of Korean Microbiological Societies.
대한민국
(2007)
Section Chair: Microbial Physiology and Genetics.
2007 International Symposium of Korean Microbiological Society.
대한민국
(2005)
Effect of spermidine on the stationary-phase morphological change in a polyamine-deficient E. coli mutant.
제6회 BK21 연구발표회.
대한민국
(2005)
Regulation of spermidine-dependent phoB::lacZ expression in E. coli.
제6회 BK21 연구발표회.
대한민국
(2004)
Polyamine dependent Protein Expression in Escherichia coli.
2004 International Meeting of the Federation of Korean Microbiological Societies.
대한민국
(2004)
Polyamine-dependent Stimulation of Transcriptional Expression of phoB in Escherichia coli.
제5회 BK21 연구발표회.
대한민국
(2004)
Requirement of polyamine for acetate utilization of Escherichia coli.
제5회 BK21 영구발표회.
대한민국
(2003)
Identification of a Novel copper inducible two component system in Escherichia coli.
제4회 BK21 연구결과 발표회.
대한민국
(2003)
Identification of the Polyamine-induced Periplasmic Protein, ZnuA.
2003 International Meeting of the Microbiological Society of Korea.
대한민국
(2002)
Polyamine Activation of arcA Transcriptional Expression in Escherichia coli.
한국미생물학회 학술대회.
대한민국
(2002)
Role of Polyamine in Osmoregulation of Escherichia coli: Polyamines Enhances Synthesis of Porines OmpC and OmpF.
제3회 연구결과 발표회.
대한민국
(2002)
Role of Polyamine in Oxidative Stress Response of Escherichia coli.
제3회 연구결과 발표회.
대한민국
(2001)
Effect of Putrescine on Induction of Escherichia coli paiAB is Mediated through ArcA.
1001th General Meeting of American Society for Microbiology.
미국
(2001)
Metabolic Engineering and Regulation.
Interfacing Microbiology & Biotechnology Conference.
미국
(2000)
Regulation of Polyamine-dependent Transcription of paiAB Operon of E. coli: ArcA is Required for Transcriptional Expression of paiAB.
한국생명과학협회 학술발표대회.
대한민국
(2000)
Role of PhoU, a Negative Regulator of Pho-regulon, in Polyamine-dependent Transcriptional Expression of paiAB Operon of E. coli: phoU+ is Required for Transcriptional Expression of paiAB.
제55회 한국생명과학협회 학술발표대회.
대한민국
(2000)
A role of polyamine in global regulation of polyamine-inducible pai genes of Escherichia coli.
생명과학 사업단 연구결과.
대한민국
(2000)
Involvement of ArcA in PA-dependent Expression of paiAB operon in Escherichia coli.
생명과학 사업단 연구결과.
대한민국
(1998)
Identification of a polyamine-inducible ope.
98th General Meeting of American Society fo.
미국
(1998)
Identification of polyamine-inducible genes.
98th General Meeting of American Society fo.
미국
